Mots-C

MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) is a 16-amino-acid peptide encoded by a short open reading frame inside the mitochondrial 12S rRNA gene, reported in 2015 as one of a small family of mitochondria-derived signalling peptides.^{25738459, 29983246} This listing supplies synthetic MOTS-c as a 10 mg lyophilized vial for laboratory research, and the batch certificate for the current lot is posted on this page. The vial is intended only for qualified research settings.

Research reagent identity

Research literature

MOTS-c is a 16-residue peptide encoded within the mitochondrial 12S rRNA region. Its published literature examines its expression and cell-signalling biology. Primary sources are linked below for researchers who need the original papers. This listing does not summarise study outcomes and makes no claim about any effect, use or benefit of this product, which is supplied as a reference material for in vitro laboratory research only.

References (PubMed): PMID 25738459, PMID 29983246, PMID 33473109, PMID 35808870, PMID 33554779, PMID 38170165, PMID 29593067, PMID 34413391, PMID 33468709, PMID 34728329, PMID 36761202, PMID 36233287

Batch documentation

The certificate card for the 10 mg variation is labelled “MOTS-c” and lists batch RRL-5532046-P, purity 99.25%, date 05 JUL 2026, lab horizonanalytical.com. Opening the purity PDF shows Revitalized Research LLC as the client, MOTS-c as the compound, CAS 1627580-64-6, the formula above, a molecular weight of about 2174.64 g/mol and an analysis by ultra-high-performance liquid chromatography with mass spectrometry: 10.15 mg found for a 10 mg specification and 99.25% purity against a >98% specification. A second PDF, lot RRL-5532046-E, is the endotoxin test and reports <0.05 EU/mL.

The suffix tells the reports apart: -P for purity, -E for endotoxin, both from one batch. Check that the lot on your vial label carries the same RRL number before you file the certificate with your records. The MOTS-C 10 mg pen listing currently shows the same batch number on its card. Every posted certificate also appears in the COA library, and our guide on how to verify a peptide COA sets out how a lot can be checked with the lab that tested it.

Storage and handling

Dry peptide keeps best sealed, cold and dark; a vial taken from the fridge should warm to room temperature before the cap is pierced, so condensation does not reach the powder. MOTS-c contains two methionines and a tryptophan, residues that are prone to oxidation, so limit air exposure and avoid repeated opening. Solvent is not packed with the peptide; reconstitution solution is offered as its own product. Handle the material in a laboratory with gloves and eye protection, and tie each prepared solution to its lot number. Temperature and light guidance is collected in peptide storage basics for research labs.

Frequently asked questions

What sequence and identifiers belong to MOTS-c?

MOTS-c is the 16-residue peptide MRWQEMGYIFYPRKLR. PubChem indexes it as CID 146675088 with CAS 1627580-64-6, formula C101H152N28O22S2 and a molecular weight of 2174.6 g/mol; the batch certificate on this page prints the same CAS and formula.

What does the certificate for this vial report?

The card shows batch RRL-5532046-P, purity 99.25%, date 05 JUL 2026 and horizonanalytical.com as the lab. Its purity report describes a UPLC-MS analysis of white lyophilized powder with 10.15 mg measured against a 10 mg specification, and the companion endotoxin report RRL-5532046-E lists less than 0.05 EU/mL.

How is the vial different from the MOTS-C pen?

The vial holds the peptide as dry lyophilized powder for a lab to reconstitute itself, while the MOTS-C 10 mg pen is a pre-filled format. Both listings concern the same 16-residue peptide; choose by the handling workflow your protocol needs.

How should an unopened MOTS-c vial be kept?

Store the sealed vial cold, dry and out of direct light, and let it reach room temperature before opening so moisture does not condense on the powder. Record the lot number whenever a solution is prepared from it.

For research use only. Not for human or animal consumption, administration, injection, topical use, medical, clinical, veterinary, food, cosmetic, supplement, household, or other personal use. This site does not provide medical advice, and this product is not intended to diagnose, treat, cure, mitigate, or prevent any disease.

These statements have not been evaluated by the Food and Drug Administration. Review the available COA or batch documentation and follow applicable laws, institutional protocols, and safety procedures before handling.

Batch documentation for Mots-C is organized by product, selected variant, and available lot when supplied. Review available COA records, purity or quality documentation, and product identifiers before purchase and before any laboratory handling.

If documentation is not displayed for a selected size or lot, contact support before ordering. Documentation is provided for research recordkeeping and product verification only.

Keep this material sealed until controlled laboratory handling. Store and handle only according to the product label, available COA or SDS, institutional SOPs, and applicable laws.

Use appropriate personal protective equipment and restrict access to qualified personnel. This material is not for human or animal consumption, administration, injection, topical use, medical, clinical, veterinary, food, cosmetic, supplement, household, or other personal use. Dispose of waste according to laboratory protocol and local requirements.