Semax

Semax is a synthetic seven-residue peptide, Met-Glu-His-Phe-Pro-Gly-Pro, designed at the Institute of Molecular Genetics in Moscow by joining the ACTH(4-7) stretch of adrenocorticotropin to a Pro-Gly-Pro tripeptide; the literature usually calls it an ACTH(4-10) analog.^{9173745, 16996037} This listing supplies Semax as a 10 mg vial of lyophilized powder for qualified laboratory research, and the batch certificate for the current lot is shown in the certificate box on this page.

Research reagent identity

The CAS number, CID, formula and molecular weight printed on the posted certificate match the PubChem record above. An N-acetylated variant (Ac-Semax) appears in the chemistry literature as a separate molecule with different metal-binding behavior, so it should not be confused with this unmodified sequence.^27586814

Research literature

Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) built from the ACTH(4-7) fragment with a C-terminal Pro-Gly-Pro extension. Most of its published literature comes from Russian laboratories and examines gene-expression and receptor-level questions in experimental models. Primary sources are linked below for researchers who need the original papers. This listing does not summarise study outcomes and makes no claim about any effect, use or benefit of this product, which is supplied as a reference material for in vitro laboratory research only.

References (PubMed): PMID 16996037, PMID 19633950, PMID 32580520, PMID 16773243, PMID 11443939, PMID 9173745, PMID 15837162

Batch documentation

When we read this page on October 2, 2026, the certificate box showed batch RRL-4383620-P, purity 99.34%, date 09 JUL 2026 and lab horizonanalytical.com. The linked purity report from Horizon Analytical (report number 1016892) lists Revitalized Research LLC as the client, a lab received date of 07/05/2026, UPLC-MS analysis conducted 07/09/2026, the compound identified as Semax, 9.82 mg found against a 10 mg specification and 99.34% purity against a >98% specification. A companion endotoxin report, lot RRL-4383620-E (report 1016891), records a pass at <0.05 EU/mL.

To tie a vial to its paperwork, compare the lot printed on the vial label with the batch on the card, then open the PDF and check that the compound, CAS and formula agree with the table above. Batch certificates are posted when available; older and newer lots sit in the Revitalized Research COA library, and the guide how to verify a peptide COA explains how to confirm a report number with the testing lab.

Storage and handling

Semax arrives as a dry cake. Keeping it sealed, cold and dark until use protects the methionine residue from oxidation and the peptide from moisture. Plan aliquots so the stock is not warmed and cooled repeatedly. Reconstitution water is not included; reconstitution solution is listed as its own item. Handle the material only in a laboratory under your institution’s protocols. General guidance for dry peptide stocks is collected in peptide storage basics for research labs.

Prefer a pen format? See Semax 10 mg (Pen). Related compounds are grouped under Neuropeptide Research.

Frequently asked questions

What is Semax, chemically?

Semax is the linear heptapeptide Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP). PubChem files it under CID 9811102 with the formula C37H51N9O10S and a molecular weight of 813.9 g/mol, and lists CAS 80714-61-0 among its synonyms. Its first four residues match positions 4 to 7 of ACTH, followed by a Pro-Gly-Pro tail.

What does the posted certificate for this Semax batch report?

The Horizon Analytical purity certificate for lot RRL-4383620-P (report 1016892, analysis conducted 07/09/2026) identifies the material as Semax by UPLC-MS, reports 9.82 mg measured against a 10 mg specification and 99.34% purity. The endotoxin report for lot RRL-4383620-E (report 1016891) lists a pass at <0.05 EU/mL.

How does the Semax vial listing differ from the Semax 10 mg pen?

Both carry the same heptapeptide. This listing is a sealed vial of dry lyophilized powder that the laboratory reconstitutes on its own schedule; the pen listing is a separate pen-format product with its own handling notes. When we checked on October 2, 2026, both pages displayed the same RRL-4383620-P certificate card.

How should lyophilized Semax be kept in the lab?

Store the unopened vial cold, dry and away from light as the label and your SOPs specify, and limit repeated warming once it is opened. Methionine-containing peptides such as Semax can oxidize, so minimizing air and moisture exposure is good practice. Reconstitution water is a separate item.

For research use only. Not for human or animal consumption, administration, injection, topical use, medical, clinical, veterinary, food, cosmetic, supplement, household, or other personal use. This site does not provide medical advice, and this product is not intended to diagnose, treat, cure, mitigate, or prevent any disease.

These statements have not been evaluated by the Food and Drug Administration. Review the available COA or batch documentation and follow applicable laws, institutional protocols, and safety procedures before handling.

Batch documentation for Semax is organized by product, selected variant, and available lot when supplied. Review available COA records, purity or quality documentation, and product identifiers before purchase and before any laboratory handling.

If documentation is not displayed for a selected size or lot, contact support before ordering. Documentation is provided for research recordkeeping and product verification only.

Keep this material sealed until controlled laboratory handling. Store and handle only according to the product label, available COA or SDS, institutional SOPs, and applicable laws.

Use appropriate personal protective equipment and restrict access to qualified personnel. This material is not for human or animal consumption, administration, injection, topical use, medical, clinical, veterinary, food, cosmetic, supplement, household, or other personal use. Dispose of waste according to laboratory protocol and local requirements.